Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity.
نویسندگان
چکیده
A solid-phase strategy using lipase as a biomolecular scaffold to produce a large amount of Cu(2+)-metalloenzyme is proposed here. The application of this protocol on different 3D cavities of the enzyme allows creating a heterogeneous artificial metallolipase showing chimeric catalytic activity. The artificial catalyst was assessed in Diels-Alder cycloaddition reactions and cascade reactions showing excellent catalytic properties.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 45 شماره
صفحات -
تاریخ انتشار 2015